The United States Government and the Government of Uganda, on Wednesday, December 10, 2025, formalized a five-year, $2.3 billion bilateral health cooperation agreement.

The Memorandum of Understanding (MOU) outlines a comprehensive vision to save lives, strengthen healthcare infrastructure, and enhance global health security, aligning with the U.S. America First Global Health Strategy.

According to the report by the US Embassy in Uganda, the United States will fund a wide spectrum of critical health programs, actively targeting major infectious diseases like HIV/AIDS, TB, and Malaria.

This support also extends to core services, including maternal and child health and polio eradication, while making significant investments in global health security, disease surveillance, and emergency preparedness.

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“This agreement represents a significant commitment by the United States and Uganda to co-invest in our shared global health priorities. Today, we are building on prior successes and making a significant shift toward promoting self-reliance in the health sector through strong community health systems, clear performance metrics, and a foundational commitment to data systems and global health security that will prevent and stop outbreaks from threatening Uganda, the United States, and the world.” Ambassador William W. Popp speaking at the signing ceremony.

A Shared Financial Commitment

The agreement is structured as a co-investment, totaling $2.3 billion over the period:

• S. Support: The U.S. Government is committed to providing up to $1.7 billion.
• Uganda’s Pledge: Critically, the Government of Uganda (GoU) pledges to increase its domestic health expenditures by more than $500 million.

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This financial framework stated a gradual reduction in foreign aid dependency, with Uganda incrementally assuming greater financial responsibility.

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President William Ruto makes a courtesy call on President Yoweri Kaguta Museveni of Uganda at Mubende State Lodge in December 2019. PHOTO/PCS.